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Highlighted publications

In vivo manipulation of human gut Bacteroides fitness by abiotic oligosaccharides.

Nature Chemical Biology. 2024.

Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo.

Elife. 2021.

Recognition of microbial glycans by soluble human lectins.

Current Opinion in Structural Biology. 2017.

Publications

* denotes equal contributions

# denotes corresponding authorship

Bold denotes Wesener Group members

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Wesener, D.A.#, Beller, Z.W., Hill, M.F., Yuan, H., Belanger, D.B., Frankfater, C., Terrapon, N., Henrissat, B., Rodionov, D.A., Leyn, S.A., Osterman, A., van Hylckama Vlieg, J.E.T., Gordon, J.I.# In vivo manipulation of human gut Bacteroides fitness by abiotic oligosaccharides. Nat. Chem. Biol. (2024). https://doi.org/10.1038/s41589-024-01763-6
Beller, Z.W., Wesener, D.A., Seebeck, T.R., Guruge, J.L., Byrne, A.E., Henrissat, S., Terrapon, N., Henrissat, B., Rodionov, D.A., Osterman, A.L., Suarez, C., Bacalzo, N.P., Chen, Y., Couture, G., Lebrilla, C.B., Zhang, Z., Eastlung, E.R., McCann, C.H., Davis, G.D., & Gordon, J.I. Inducible CRISPR-targeted “knockdown” of human gut Bacteroides in gnotobiotic mice discloses glycan utilization strategies. Proc. Natl. Acad. Sci. U.S.A. 120, e2311422120 (2023). https://doi.org/10.1073/pnas.2311422120
McPherson, R.L., Isabella, C.R., Walker, R.L., Sergio, D., Bae, S., Gaca, T., Raman, S., Nguyen, L.T.T., Wesener, D.A., Halim, M., Wuo, M.G., Dugan, A., Kerby, R., Ghosh, S., Rey, F.E., Dhennelez, C., Pishchany, G., Lensch, V., Vlamakis, H., Alm, E.J., Xavier, R.J., & Kiessling, L.L. Lectin-Seq: A method to profile lectin-microbe interactions in native communities. Sci. Adv. 9, eadd8766 (2023). https://doi.org/10.1126/sciadv.add8766
Wesener, D.A., Beller, Z.W., Peters, S.L., Rajabi, A., Dimartino G., Giannone R.J., Hettich R.L. & Gordon, J.I. Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo. eLife. 10, e64478 (2021). https://doi.org/10.7554/eLife.64478
Wolf, A.R., Wesener, D.A., Cheng, J., Houston-Ludlam, A.N., Beller, Z.W., Hibberd, M.C., Giannone, R.J., Peters, S.L., Hettich, R.L., Leyn, S.A., Rodionow, D.A., Osterman, A.L., & Gordon, J.I. Bioremediation of a common product of food processing by a human gut bacterium. Cell Host Microbe. 26, 463-477 (2019). https://doi.org/10.1016/j.chom.2019.09.001
Wesener, D.A., Dugan, A., & Kiessling L.L. Recognition of microbial glycans by soluble human lectins. Curr. Opin. Struct. Biol. 44, 168-178 (2017). https://doi.org/10.1016/j.sbi.2017.04.002
Wesener, D.A.*, Levengood, M.R.*, & Kiessling L.L. Comparing galactan biosynthesis in Mycobacterium tuberculosis and Corynebacterium diphtheriae. J. Biol. Chem. 292, 2944-2955 (2017). https://doi.org/10.1074/jbc.M116.759340
Wangkanont, K., Wesener, D.A., Vidani, J.A., Kiessling, L.L., & Forest, K.T. Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition. J. Biol. Chem. 291, 5596-5610 (2016). https://doi.org/10.1074/jbc.M115.709212
Wesener, D.A., Wangkanont, K., McBride, R., Song, X., Kraft, M.B., Hodges, H.L., Zarling, L.C., Splain, R.S., Smith D.F., Cummings, R.D., Paulson, J.C., Forest, K.T., & Kiessling, L.L. Recognition of microbial glycans by human intelectin-1. Nat. Struct. Mol. Biol. 22, 603-610 (2015). https://doi.org/10.1038/nsmb.3053
Kincaid, V.A., London, N., Wangkanont, K., Wesener, D.A., Marcus, S.A., Heroux, A., Nedyalkova, L., Talaat, A.M., Forest, K.T., Shoichet, B.K., & Kiessling, L.L. Virtual screening for UDP-galactopyranose mutase ligands identifies a novel class of antimycobacterial agents. ACS Chemical Biol. 10, 2209-2218 (2015). https://doi.org/10.1021/acschembio.5b00370
Wesener, D.A., May, J.M., Huffman, E.M., & Kiessling, L.L. UDP-Galactopyranose mutase in Nematodes. Biochemistry. 52, 4391-98 (2013). https://doi.org/10.1021/bi400264d
Armstrong, B.D., Choi, J., López, C., Wesener, D.A., Hubbell, W., Cavagnero, S., & Han, S. Site–specific hydration dynamics in the nonpolar core of a molten globule by dynamic nuclear polarization of water. J. Am. Chem. Soc. 133, 5987-95 (2011). https://doi.org/10.1021/ja111515s

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